Figure 4. Augurin immunoreactivity in the supraoptic nucleus (SON) of the hypothalamus does not decrease following penetrating CNS injury.

To demonstrate specificity of injury response in the CPe as opposed to other regions of the brain that have high levels of Ecrg4 gene and augurin protein expression [21], we examined the SON of the hypothalamus in injured rats at 1 (Panel B), 3 (Panel C) and 7 (Panel D) d.p.i. and compared staining in intact brain (Panel A). While there may have been a slight incrase at 3 and 7 d.p.i., the precipitous decline of expression that occurred in the CPe following injury was not observed in SON. Images representative of n = 3 rats.