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. 2011 Oct 15;204(8):1246–1255. doi: 10.1093/infdis/jir508

Figure 2.

Figure 2.

Skeletal muscle insulin signaling pathway protein expression. Protein expression of members of the insulin signaling pathway (insulin receptor substrate 1 [IRS-1], insulin receptor substrate 2 [IRS-2], and insulin receptor β subunit [IRβ]) and downstream targets (Akt1, Akt2, and glucose transporter type 4 [GLUT4]) in skeletal muscle of control animals (n = 8), sucrose-treated simian immunodeficiency virus (SIV)–infected (SUC/SIV+) animals (n = 9), and chronic binge alcohol-administered SIV-infected (ALC/SIV+) animals (n = 11). Shown are representative Western blot images and below mean (± SEM) densitometry values. Expression was normalized to ß-actin and expressed as fold change of control values. There were no statistical differences in variables analyzed using 1-way analysis of variance with a Kruskal-Wallis test followed by a Dunn multiple comparisons test.