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. Author manuscript; available in PMC: 2012 Sep 14.
Published in final edited form as: Chem Rev. 2011 Jul 25;111(9):5492–5505. doi: 10.1021/cr2000509

Figure 3.

Figure 3

Effect of rifampicin and oligomycin on development of S. coelicolor. Each well (edge visible at left) contains 60μl of a 20μg/ml solution of each drug. A) Rifampicin, a transcription inhibitor, causes a range of phenotypes across a diffusion gradient. This is visible as accelerated aerial hyphae and actinorhodin production near the well. B) The mitochondrial ATP synthase inhibitor oligomycin A causes a zone of growth inhibition, followed by an area of altered secondary metabolite production and aerial hyphe development. (Microscopy: Matt Traxler, Oligomycin A purified by Gavin Carr)