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Catalyst structure-activity relationship study
 | |||||
|---|---|---|---|---|---|
| entry | catalyst | 0 mol% 8 | 15 mol% 8 | ||
| yield (%)a | ee (%)b | yield (%)a | ee (%)b | ||
| 1 | 10 | 32 | 72 | 72 | 91 |
| 2 | 31 | 7 | n.d. | 58 | 71 |
| 3 | 32 | 7 | n.d. | 58 | −85 |
| 4 | 33 | 10 | n.d. | 11 | n.d. |
Reactions performed on a 0.05 mmol scale.
Determined by 1H NMR analysis using 1,3,5-trimethoxybenzene as an internal standard.
Determined by HPLC using commercial chiral columns.
