An official website of the United States government
Here's how you know
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Major Features of SLE that should be Accommodated by Hypotheses of SLE Pathogenesis
Protean clinical presentations at the initial diagnosis and in relapses with each patient having a unique clinical course;
Interactive and independent nature of autoimmunity and end organ damage;
Unique patterns of autoantibody diversification to linked autoantigen sets such as SmD, SmB, and RNP proteins and the diversification process over a period of years; and
Dominant role of HLA-D regions in SLE susceptibility.