Skip to main content
. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Autoimmun. 2011 Jun 1;37(2):104–112. doi: 10.1016/j.jaut.2011.05.004

Table 2.

Major Features of SLE that should be Accommodated by Hypotheses of SLE Pathogenesis

  1. Protean clinical presentations at the initial diagnosis and in relapses with each patient having a unique clinical course;

  2. Interactive and independent nature of autoimmunity and end organ damage;

  3. Unique patterns of autoantibody diversification to linked autoantigen sets such as SmD, SmB, and RNP proteins and the diversification process over a period of years; and

  4. Dominant role of HLA-D regions in SLE susceptibility.