P22phox, P47phox and P67phox mRNA expression (A) and protein (B) in the PVN, SON and cortex of rats after icv infusion of vehicle, aldosterone (Aldo), aldosterone plus benzamil (Aldo+Benz), or aldosterone plus Digibind (Aldo+Digib) for 2 weeks.
mRNA levels are expressed relative to the levels in rats treated with vehicle, assigned a value of 1.
Data are means±SEM (n= 4/ group).
For P22phox, F=3.2 (p=0.01) for mRNA in the PVN; and F=5.3 (p=0.004) for mRNA and F=6.4 (p=0.003) for protein in the SON.
For P47phox, F=6.2 (p=0.003) for mRNA; and F=7.3 (p=0.001) for protein in the PVN.
For P67phox, F=6.3 (p=0.003) for mRNA; and F=7.3 (p=0.001) for protein in the PVN.
* p<0.05, versus vehicle.