nNOS and eNOS mRNA expression (A) and protein (B) in the PVN, SON and cortex of rats after icv infusion of vehicle, aldosterone (Aldo), aldosterone plus benzamil (Aldo+Benz), or aldosterone plus Digibind (Aldo+Digib) for 2 weeks.
mRNA levels are expressed relative to the levels in rats treated with vehicle, assigned a value of 1.
Data are means±SEM (n= 4/group).
For nNOS, F=5.3 (p=0.004) for mRNA; and F=8.7 (p=0.0003) for protein in the PVN.
F=3.2 (p=0.007) for mRNA; and F=6.4 (p=0.003) for protein in the SON.
* p<0.05, versus vehicle.