Table 2.
ACE and AT1R binding densities measured by autoradiography in the PVN and SON in rats treated with icv infusion of vehicle, aldosterone (Aldo), aldosterone plus benzamil (Aldo+Benz), or aldosterone plus Digibind (Aldo+Digib) for 2 weeks.
| N | vehicle | Aldo | Aldo+Benz | Aldo+Digib | |
|---|---|---|---|---|---|
| AT1R densities (fmol/mg) | |||||
| mPVN | 6 | 468±16 | 635±21* | 465±17# | 508±26# |
| pPVN | 6 | 370±14 | 476±16* | 370±12# | 402±18# |
| SON | 6 | 128±7 | 170±10* | 138±7# | 146±12 |
| ACE densities (fmol/g) | |||||
| mPVN | 6 | 1740±57 | 2129±89* | 1834±59# | 1857±94# |
| pPVN | 6 | 669±39 | 883±37* | 757±60 | 788±34 |
| SON | 6 | 1057±39 | 1381±43* | 1236±74 | 1297±88* |
Data are means±SEM.
*
p<0.05, vs vehicle
#
p<0.05, vs aldosterone.
mPVN: magnocellular region of paraventricular nucleus
pPVN: parvocellular region of paraventricular nucleus
SON: supraoptic nucleus.