Table 3.
Analysis of the effect of age on the expression of alternatively-spliced isoforms.
| Gene | id | isoform | Mean | se | Comparison | Coeff | CI | CI | p-value |
|---|---|---|---|---|---|---|---|---|---|
| ABLIM1 | |||||||||
| 1 | ilmn_1731610 | NM_006720.3 | 102.29 | 6.21 | |||||
| 2 | ilmn_2396672 | all | 115.61 | 10.49 | 1 / 2 | 0.0009 | 0.0006 | 0.0012 | <0.0001 |
| 3 | ilmn_1785424 | all | 209.54 | 53.73 | 1 / 3 | 0.0032 | 0.0027 | 0.0037 | <0.0001 |
| STAT1 | |||||||||
| 4 | ilmn_1777325 | NM_007315.3 | 317.9793 | 145.709 | |||||
| 5 | ilmn_1691364 | NM_139266.2 | 715.9618 | 329.8048 | 4 / 5 | −0.0026984 | −0.0033706 | −0.0020263 | 0.0033706 |
| CD79A | |||||||||
| 6 | ilmn_2410371 | NM_001783.3 | 94.26653 | 4.791344 | |||||
| 7 | ilmn_1734878 | all | 338.5959 | 213.6811 | 6 / 7 | 0.0028078 | 0.0021338 | 0.0034817 | 0.0021338 |
| HSPD1 | |||||||||
| 8 | ilmn_1784367 | NM_002156.42 | 96.76617 | 3.201362 | |||||
| 9 | ilmn_1766713 | all | 142.1247 | 19.87898 | 8 / 9 | 0.0012785 | 0.0008516 | 0.0017055 | 0.0008516 |
| CASP8 | |||||||||
| 10 | ilmn_1750596 | NM_024793.1 | 100.70 | 3.63 | |||||
| 11 | ilmn_2242491 | NM_024793.1 | 10361.48 | 1983.51 | 7 / 8 | 0.0000 | 0.0000 | 0.0000 | <0.0001 |
| LAMP2 | |||||||||
| 12 | ilmn_1752351 | NM_013995.2 | 238.35 | 52.02 | 12 / 14 | −0.0004 | −0.0011 | 0.0002 | 0.208 |
| 13 | ilmn_2279961 | NM_013995.2 | 261.87 | 83.04 | 12 / 13 | −0.0016 | −0.0030 | −0.0002 | 0.027 |
| 14 | ilmn_1673282 | NM_002294.2 | 354.04 | 97.12 | |||||
| MAX | |||||||||
| 15 | ilmn_1695633 | NM_145116.1 | 93.97 | 4.54 | 15 / 16 | −0.0001 | −0.0003 | 0.0002 | 0.578 |
| 16 | ilmn_1802457 | NM_145114.1 | 107.29 | 3.99 | 15 / 17 | −0.0002 | −0.0004 | 0.0001 | 0.155 |
| 17 | ilmn_1706546 | NM_145113.1 | 108.31 | 5.55 | 16 / 17 | −0.0001 | −0.0004 | 0.0002 | 0.423 |
| SON | |||||||||
| 18 | ilmn_1663090 | NM_032195.1 | 106.31 | 4.13 | |||||
| 19 | ilmn_2247664 | NM_138927.1 | 200.96 | 45.44 | 18 / 19 | 0.0017 | 0.0011 | 0.0023 | <0.0001 |
| WTAP | |||||||||
| 20 | ilmn_1734544 | NM_004906.3 | 238.35 | 52.02 | |||||
| 21 | ilmn_2279339 | NM_004906.3 | 261.87 | 83.04 | 20 / 22 | 0.0003 | −0.0002 | 0.0009 | 0.208 |
| 22 | ilmn_1657618 | NM_152857.1 | 354.04 | 97.12 | 21 / 22 | 0.0015 | −0.0014 | 0.0044 | 0.305 |
The ratio of alternatively expressed isoforms of specific genes in relation to increasing age is given in the table above. Association with age is calculated by logistic regression. Id = probe identity, isoform = transcript identity, Mean = mean ratio, se = standard error, comparison indicates which transcripts were used for the analysis, coeff = correlation coefficient, CI = confidence intervals. The analysis was carried out on 689 individuals.