Figure 1.
Effect of ghrelin on water, 1.8% NaCl, and food intakes after I.C.V. administration of AngII when food was available during fluid intake testing (Experiment 1A). In a 4 h test, ghrelin reduced 30-min saline intake (A) but had no effect on non-cumulative water intake (B). Total saline intake and total fluid intake were also attenuated in ghrelin-treated rats (C). Ghrelin reliably stimulated food intake (D). In Panel C, groups of vehicle- and ghrelin-treated rats are respectively abbreviated “Veh” and “Ghr.” All data are shown as mean ± SEM (n=5–6 per treatment group) and asterisks indicate p<0.05 compared to controls.