Fig. 2.

Turnover of peroxisomes. The major pathway of peroxisome degradation is autophagy. A In macropexophagy a pre-autophagosomal structure (PAS), probably formed from the ER, engulfs the peroxisome thus forming an autophagosome that fuses with the vacuole, delivering the organelle for degradation by vacuolar hydrolases. B In micropexophagy the peroxisome is directly engulfed by the vacuolar membrane and subsequently degraded in the vacuolar lumen. C Peroxisomes can be also degraded by the activity of 15-lipoxygenase (15-LOX) that disturbs the integrity of peroxisomal membrane