Table 3.

Adjusted mean PGWB total scores by baseline severity of heartburn symptoms

Trial/Follow-up		n	Mean (s.e.)
Clinical Trial 1
8 Weeks	None/Minor	59	80.5 (1.6)
	Mild	159	80.3 (1.0)
	Moderate	59	82.0 (1.6)
	Severe	13	87.5 (3.5)
Clinical Trial 2
4 Weeks	None/Minor	237	82.4 (0.8)
	Mild	219	81.8 (0.9)
	Moderate	160	82.5 (1.0)
	Severe	33	82.3 (2.2)
8 Weeks	None/Minor	234	83.4 (0.9)
	Mild	219	82.1 (0.9)
	Moderate	155	83.7 (1.1)
	Severe	35	82.3 (2.3)
12 Weeks	None/Minor	231	84.4 (0.9)
	Mild	217	83.1 (1.0)
	Moderate	151	85.8 (1.2)
	Severe	34	82.5 (2.4)
16 Weeks	None/Minor	229	86.0 (0.9)
	Mild	211	84.8 (1.0)
	Moderate	153	88.4 (1.2)
	Severe	32	86.8 (2.5)
Clinical Trial 3
4 Weeks	None/Minor	40	76.0 (3.0)
	Mild	21	73.7 (3.9)
	Moderate	79	72.8 (2.0)
	Severe	84	70.9 (2.0)
12 Weeks	None/Minor	37	76.9 (3.2) *
	Mild	17	71.9 (4.5)
	Moderate	71	74.0 (2.3)
	Severe	69	64.3 (2.4)
24 Weeks	None/Minor	37	74.5 (3.5)
	Mild	18	69.6 (4.8)
	Moderate	68	72.4 (2.5)
	Severe	74	67.4 (2.4)

*p < 0.05 for test of overall differences in least square means from ANCOVA model, adjusted for gender, age, relevant baseline PGWB total score, and symptom resolution status.