Table 4.

Adjusted mean Sleep Disturbance scores by baseline severity of heartburn symptoms

Trial/Follow-up		N	Mean (s.e.)
Clinical Trial 1
8 Weeks	None/Minor	59	75.0 (2.3)
	Mild	158	73.9 (1.5)
	Moderate	58	77.3 (2.4)
	Severe	13	74.3 (5.1)
Clinical Trial 3
4 Weeks	None/Minor	39	75.7 (3.8)
	Mild	20	69.2 (5.1)
	Moderate	72	72.4 (2.7)
	Severe	79	66.4 (2.6)
12 Weeks	None/Minor	36	75.0 (3.8) *
	Mild	16	70.8 (5.6)
	Moderate	66	71.3 (2.9)
	Severe	65	62.8 (2.9)
24 Weeks	None/Minor	33	75.6 (4.3)
	Mild	14	73.3 (6.4)
	Moderate	63	70.0 (3.1)
	Severe	69	66.3 (3.0)

*p < 0.05 for test of overall differences in least square means from ANCOVA model, adjusted for gender, age, relevant baseline sleep disturbance score, and symptom resolution status.