Table 3.
Interleukin-17 (IL-17) family cytokines and receptors in human disease
| Disease | Expression | References | |
|---|---|---|---|
| IL-17A | RA | Elevated | 46,89 |
| IBD | Elevated | 40 | |
| Psoriasis | Elevated | 9,42,44 | |
| MS | Elevated | 41 | |
| Atherosclerosis | Elevated | 55 | |
| IL-17B | Psoriasis | Reduced | 9 |
| IL-17C | Psoriasis | Elevated | 9 |
| IL-17D | Psoriasis | Reduced | 9 |
| IL-17E | Asthma | Elevated | 64,75 |
| Atopic dermatitis | Elevated | 64 | |
| IBD | Reduced | 79 | |
| IL-17F | RA | Elevated | 94–96 |
| IBD | Elevated | 43 | |
| Psoriasis | Elevated | 9,42 | |
| IL-17RA | RA | Elevated | 94,95 |
| IBD | Elevated | 96 | |
| IL-17RB | Asthma | Elevated | 64,107 |
| Atopic dermatitis | Elevated | 64 | |
| IL-17RC | RA | Elevated | 95 |
IBD, inflammatory bowel disease; MS, multiple sclerosis; RA, rheumatoid arthritis.