Table 1.
Effect of phosphatidyl inositol 3-kinase inhibitors on viability of monocyte-derived dendritic cells
| Condition | Cell viability (%) |
|---|---|
| Immature dendritic cells | 100 |
| Mature dendritic cells | 100 |
| Wortmannin 0·03 μm | 100 |
| Wortmannin 0·1 μm | 100 |
| Wortmannin 0·3 μm | 100 |
| Wortmannin 1 μm | 100 |
| LY294002 1 μm | 100 |
| LY294002 3 μm | 100 |
| LY294002 10 μm | 100 |
| LY294002 30 μm | 47 |
Monocyte-derived DC were treated with the indicated concentration of phosphatidyl inositol 3-kinase inhibitors for 24 hr and their viability was determined by dye-exclusion. Results shown are % viability from a representative donor and viability was monitored in all experiments.