Table 3.

Effect of Wortmannin (WM) on secretion of interleukin-1β and interleukin-23 from mature monocyte-derived dendritic cells

Cytokine	0 μm WM (pg/ml ± SD)	1 μm WM (pg/ml ± SD)	P value
Interleukin-1β	12 ± 7	65 ± 60	0·054
Interleukin-23	1337 ± 700	17374 ± 8404	< 0·01

Monocyte-derived dendritic cells were generated from an additional six donors and their secretion of interleukin-1β and interleukin-23 in response to lipopolysaccharide was determined in the absence or presence of WM. Shown is the cytokine secretion at 24 hr as determined by ELISA ± SD