Table 2.

Linear mixed effects modeling of TIL infiltration, performed on a cohort of 50 patients to estimate the magnitude of the difference between intraepithelial and stromal TIL infiltration at primary (ovarian) and metastatic sites

Intraepithelial TILs
	CD3		CD8		FoxP3
Site	Avg. Diff. (95% CI)	p value	Avg. diff. (95% CI)	p value	Avg. diff. (95% CI)	p value
Primaries (ovaries)	(ref)	(ref)	(ref)	(ref)	(ref)	(ref)
Metastases	−0.07 (−0.30, 0.17)	0.57	−0.09 (−0.29, 0.12)	0.40	0.12 (−0.14, 0.17)	0.37
Significant global effects?	No, p = 0.30		No, p = 0.35		No, p = 0.32
Stromal TILs
	CD3		CD8		FoxP3
Site	Avg. Diff. (95% CI)	p value	Avg. diff. (95% CI)	p value	Avg. diff. (95% CI)	p value
Primaries (ovaries)	(ref)	(ref)	(ref)	(ref)	(ref)	(ref)
Metastases	0.41 (0.21, 0.62)	0.020	0.39 (0.20, 0.57)	0.00002	0.22 (0.04, 0.47)	0.086
Significant global effects?	Yes, p = 0.0003		Yes, p = 0.0001		Yes, p = 0.0003