Table 2.

Cognitive function scores by NT-proBNP level (mean ± SD) in men and women

	All Participants NT-proBNP*			Men NT-proBNP*			Women NT-proBNP*
Model	Low (n=752)	High (n=198)	p	Low (n=299)	High (n=72)	p	Low (n=453)	High (n=126)	p
MMSE Score
Unadjusted	27.5 ± 1.8	26.4 ± 2.9	<0.001	27.4 ± 1.7	26.3 ± 2.9	0.004	27.6 ± 1.9	26.4 ± 2.8	<0.001
Age, sex, education†	27.3 ± 2.0	26.9 ± 2.1	0.012	27.2 ± 1.9	27.0 ± 2.0	0.58	27.4 ± 2.0	26.9 ± 2.1	0.010
All covariates†‡	27.3 ± 2.0	26.9 ± 2.1	0.013	27.2 ± 1.9	27.0 ± 2.0	0.56	27.4 ± 2.0	26.9 ± 2.2	0.014
All covariates + prior CVD	27.3 ± 2.0	26.9 ± 2.1	0.021	27.2 ± 1.9	27.0 ± 2.0	0.60	27.4 ± 2.0	26.9 ± 2.2	0.022
Trails B Score§
Unadjusted	114 ± 59	162 ± 77	<0.001	106 ± 54	157 ± 78	<0.001	120 ± 62	165 ± 76	<0.001
Age, sex, education†	120 ± 57	141 ± 60	<0.001	111 ± 54	134 ± 57	0.003	125 ± 59	145 ± 61	0.005
All covariates†‡	121 ± 57	139 ± 60	<0.001	111 ± 54	133 ± 58	0.007	127 ± 59	142 ± 62	0.015
All covariates + prior CVD	121 ± 57	137 ± 60	0.001	111 ± 54	132 ± 58	0.012	127 ± 59	140 ± 63	0.042
Category Fluency Score
Unadjusted	18.1 ± 4.9	15.7 ± 4.9	<0.001	18.8 ± 5.0	16.8 ± 5.3	0.002	17.7 ± 4.8	15.1 ± 4.5	<0.001
Age, sex, education†	17.8 ± 4.6	17.0 ± 4.8	0.031	18.5 ± 4.9	18.1 ± 5.2	0.53	17.4 ± 4.4	16.3 ± 4.6	0.016
All covariates†‡	17.8 ± 4.6	17.0 ± 4.9	0.056	18.5 ± 4.9	18.2 ± 5.3	0.63	17.3 ± 4.4	16.4 ± 4.7	0.062
All covariates + prior CVD	17.8 ± 4.7	17.1 ± 5.0	0.078	18.5 ± 4.9	18.1 ± 5.3	0.60	17.3 ± 4.4	16.5 ± 4.8	0.10

^*For NT-proBNP groups, "Low" is <450 pg/ml; "High" is ≥450 pg/ml.

CVD=cardiovascular disease; MMSE = Mini Mental State Exam

^†Not adjusted for sex in sex-stratified analyses.

^‡All covariates = age, sex, education, hypertension, BMI, exercise, alcohol use, current smoking, LDL cholesterol, creatinine clearance, and estrogen use (for women only).

^§For Trails B, lower score is better; n=939 (747 with low NT-proBNP, 192 with high NT-proBNP).