Table 3.

Association of high NT-proBNP with poor performance on cognitive function tests.

Model	All Participants (n=950) OR (95% CI)*	Participants Without Prior Stroke (n=892) OR (95% CI)*	Participants Without Prior CVD (n=768) OR (95% CI)*
MMSE
Unadjusted	3.76 (2.29–6.17)	4.12 (2.44–6.95)	3.81 (2.12–6.87)
Age, sex, education	2.04 (1.18–3.52)	2.18 (1.22–3.90)	1.90 (0.98–3.72)
All covariates†	1.96 (1.09–3.52)	2.03 (1.10–3.78)	1.62 (0.80–3.29)
All covariates + prior CVD	1.98 (1.09–3.57)	2.13 (1.14–3.98)	N/A
Trails B‡
Unadjusted	3.78 (2.72–5.26)	3.62 (2.56–5.13)	3.48 (2.33–5.20)
Age, sex, education	1.84 (1.26–2.67)	1.67 (1.12–2.49)	1.47 (0.93–2.34)
All covariates†	1.80 (1.21–2.67)	1.69 (1.11–2.57)	1.49 (0.92–2.43)
All covariates + prior CVD	1.66 (1.12–2.48)	1.64 (1.07–2.51)	N/A
Category Fluency
Unadjusted	2.72 (1.85–4.01)	2.90 (1.93–4.35)	2.47 (1.54–3.95)
Age, sex, education	1.54 (1.004–2.36)	1.62 (1.03–2.55)	1.26 (0.74–2.13)
All covariates†	1.36 (0.86–2.13)	1.43 (0.89–2.31)	1.09 (0.62–1.90)
All covariates + prior CVD	1.36 (0.86–2.15)	1.46 (0.90–2.36)	N/A

^*Odds ratio is for risk of poor performance in participants with High vs. Low NT-proBNP

^†All covariates = age, sex, education, hypertension, BMI, exercise, alcohol use, current smoking, LDL cholesterol, creatinine clearance

CVD = cardiovascular disease; MMSE = Mini Mental State Exam; OR = odds ratio

^‡For Trails B testing, n=939 (883 without prior stroke; 761 without prior CVD).