TABLE 3.
Comparison of Observed and Expected Cases of Clinical Conditions Among the Grandchildren of Pink Disease Survivors Aged 6–16 Years at 2005 (n = 539)
| Condition | Observed cases | Expected cases | SIR | 95% confidence interval | 1-Sided Poisson Probability (P) |
|---|---|---|---|---|---|
| ASD | 20 | 2.85 | 7.02 | 4.28–10.84 | <0.0001 |
| ADHD | 13 | 20.75 | 0.63 | 0.33–1.07 | 0.97 |
| Epilepsy | 3 | 3.67 | 0.82 | 0.16–2.39 | 0.71 |
| Fragile X syndrome | |||||
| Males | 0 | 0.14 | 0.00 | ∗-26.20 | 1.00 |
| Females | 1 | 0.13 | 7.69 | 0.10–42.80 | 0.12 |
| Down syndrome | 0 | 0.67 | 0.00 | ∗-5.47 | 1.00 |
Note. SIR = Standardized incidence ratios; ASD = autism spectrum disorder; ADHD = attention deficit hyperactivity disorder; Asterisk indicates lower limit for fragile X males and down syndrome not calculable; Data for males and females were pooled unless otherwise stated.