Table 3.

Cox proportional hazards model for transition to dementia comparing specificity of conventional MCI-R criteria when additional clinical characteristics are added

MEN
	Roc curves		Cox models
MCI Groups	Specificity %	AUC	Beta coefficient	Wald	p	Hazard Ratios 95 % IC *
MCI –R	60	0.642	1.10	32.61	<0.001	3.01 [2.1–4.4]
MCI-R+APOE ε4	92	0.566	1.27	30.83	<0.001	3.58 [2.3–5.6]
MCI-R+stroke	97	0.531	1.42	20.13	<0.001	4.15 [2.2–7.7]
MCI-R+IADL	97	0.564	1.52	34.73	<0.001	4.57 [2.5–7.6]

WOMEN
	Roc curves		Cox models
MCI Groups	Specificity %	AUC	Beta coefficient	Wald	p	Hazard Ratios 95 % IC *
MCI –R	60	0.604	0.76	23.35	<0.001	2.1 [1.6–2.9]
MCI-R+anticholinergic drug	95	0.553	0.83	13.70	<0.001	2.3 [1.5–3.5]
MCI-R+APOE ε4	92	0.531	1.03	27.28	<0.001	2.8 [1.9–4.1]
MCI-R+depression	93	0.561	1.02	28.53	<0.001	2.8 [1.9–4.1]

^*Cox models adjusted by age, education level, centre

AUC: Area Under the Curve