Table 2.
Clinicopathologic characteristics of the nine patients with glioblastoma analyzed
| Patient code | Sex | Age at diagnosis (years) | Status WHOa | Delay 1st symptoms - diagnosis (days) | GBM nature | Tumor location | Extent of surgery | Associated treatment | Delay of recurrence (months) | Follow-up (months) | Survival (months) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 | F | 72 | 1 | 15 | de novo | Frontal | Radical | RC | Uk | Uk | Uk |
| G2 | M | 72 | 1 | 21 | de novo | Parietal | Partial | R | 4 | 17 | 17 |
| G3 | M | 65 | 2 | 60 | de novo | Temporal | Radical | RC | 4 | 5 | 7 |
| G4 | M | 56 | 1 | 30 | de novo | Frontal | Partial | RC | 11 | 17 | 17 |
| G5 | M | 47 | 1 | 21 | de novo | Parietal | Radical | RC | 12 | 18 | 18 |
| G6 | M | 32 | 1 | 21 | de novo | Frontal | Partial | RC | 4 | 18 | 18 |
| G7 | F | 41 | 0 | 90 | de novob | Temporal | Repeated | C | 6 | 14 | Uk |
| G8 | M | 20 | 0 | 60 | de novob | Frontal | Repeated | C | 10 | 17 | 17 |
| G9 | M | 26 | 1 | 30 | secondary | Frontal | Radical | C | 9 | 3 | 30 |
a
WHO clinical status before surgery was graded as follows: Status WHO 0: Karnofsky = 100, no clinical symptoms; Status WHO 1: 80 < Karnofsky < 90, minor symptoms such as visual amputation or headaches; Status WHO 2: 60 < Karnofsky < 70, confined to bed < 50% of the day; Status WHO 3: 40 < Karnofsky < 50, confined to bed > 50% of the day; Status WHO 4: 20 < Karnofsky < 30, bedridden
b
Samples retrieved during surgery for recurrence
Abbreviations: GBM, glioblastoma multiforme (WHO IV); M, male; F, Female; RC, radiotherapy with concomitant temozolomide chemotherapy; R, radiotherapy; C, chemotherapy; Uk, unknown.