Table 3.
Laboratory parameters values
| group I (n = 35) | group II (n = 73) | group III (n = 95) | cut-off point | |
| PT [sec] | 11.3 (10.8–12.3) | 10.8 (10.4–11.6) | 24.0 a (20.4–29.4) | 13.21 (0.979, 0.990) |
| INR | 1.02 (0.98–1.11) | 0.98 (0.92–1.04) | 2.16 a (1.84–2.60) | 1.20 (0.979, 0.990) |
| APTT ratio | 1.01 (0.96–1.10) | 0.98 (0.92–1.10) | 1.17 a (1.08–1.33) | 1.03 (0.870, 0.645) |
| Fibrinogen [g/l] | 3.36 (2.85–3.83) | 3.60 (3.19–4.09) | 4.17 b (3.59–4.63) | 4.13 (0.537, 0.815) |
| FII [%] | 132 (117–142) | 133 (122–145) | 25 a (19–35) | 83.0 (0.989, 0.971) |
| FVII [%] | 125 (108–133) | 135 (125–142) | 47 a (32–64) | 91.1 (0.946, 0.963) |
| FX [%] | 108 (92–120) | 104 (96–113) | 15 a (11–20) | 68.1 (1.0, 0.942) |
| protein C [%] | 118 (103–138) | 125 (110–137) | 54 a (46–64) | 91.0 (0.968, 0.935) |
| prothrombin F1+2 [ng/ml] | 0.87 (0.57–1.26) | 1.26 c (0.98–1.71) | 0.27 a (0.19–0.40) | 0.528 (0.840, 0.934) |
Data represent median and 25–75 percentile range. Cut-off points between users (group III) and non-users of OAT (groups I and II) estimated by ROC curve analysis with an a priori weighing of sensitivity:specificity ratio equal 1.0; the post hoc sensitivity and specificity estimates given in parentheses. Significance of differences between groups estimated for normalized data by one-way ANOVA (p « 0.0001 for all variables) and Tukey's test for multiple comparisons: a p « 0.0001; b p < 0.0002; c p < 0.05.