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. 2011 Aug 5;30(18):3823–3829. doi: 10.1038/emboj.2011.263

Figure 3.

Figure 3

FBF represses the cki-2 3′UTR reporter in stem cells. (A) The wild-type cki-2 3′UTR reporter is partially derepressed in dividing stem cells of fbf-1 fbf-2 mutant L4 animals. Gonads (outlined) from live fbf-1 fbf-2 mutant and fbf-1 fbf-2/+ heterozygote sibling L4 animals are shown. Boxed areas are magnified on the left. Quantification of GFP signal in distal-most cells is shown below (n=number of examined gonads, error bars=s.e.m.). ***Indicates the P-value of 1.298e-05 (see Materials and methods). (B) The FBE1–4 region mediates repression at the L4 stage. A cki-2 3′UTR reporter lacking the FBE1–4 region is derepressed in stem cells of L4 animals. Scale bars: 50 μm.