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. Author manuscript; available in PMC: 2011 Sep 15.

Published in final edited form as: Nature. 2010 Sep 2;467(7311):52–58. doi: 10.1038/nature09298

a, b, Mean r² between true and imputed genotype dosage as a function of copies of minor allele in the reference panel. a, The loss in imputation accuracy when the reference population differs slightly from the target population (CEU imputed into CEU compared to CEU into TSI; and YRI into YRI compared to YRI into LWK). b, Imputation accuracy for newly discovered variants (CNPs and ENCODE SNPs).

a, b, Mean r² between true and imputed genotype dosage as a function of copies of minor allele in the reference panel. a, The loss in imputation accuracy when the reference population differs slightly from the target population (CEU imputed into CEU compared to CEU into TSI; and YRI into YRI compared to YRI into LWK). b, Imputation accuracy for newly discovered variants (CNPs and ENCODE SNPs).