Table 3.
Effect of feeding different combinations on hepatic lipid profiles, HMG-CoA reductase activity and bile acid content (mg/gm).
| Group | NC | HC | C-I | C-II | C-III |
|---|---|---|---|---|---|
| Total lipids | 30 ± 2.9d | 126.8 ± 4.3a (+322.76) | 91.7 ± 3.1bc (−27.72) | 83.8 ± 3.2c (−33.90) | 101.3 ± 3.1b (−20.10) |
| Total cholesterol | 1.9 ± 0.1d | 36.1 ± 1.7a (+1769.43) | 24.9 ± 1.5bc (−30.90) | 23.5 ± 1.3bc (−34.75) | 29 ± 1.4b (−19.53) |
| Triglycerides | 3 ± 0.1b | 24.3 ± 1.4a (+705.96) | 20.2 ± 1.2a (−17.00) | 22.1 ± 1.7a (−9.20) | 22.3 ± 1.8a (−8.50) |
| HMG CoA reductase* | 2.8 ± 0.1e | 7.1 ± 0.1a (−156.67) | 6 ± 0.1bc (+15.75) | 5.8 ± 0.1cd (+18.84) | 6.2 ± 0.1b (+12.93) |
| Bile acid | 3.8 ± 0.1d | 6.9 ± 0.1c (+83.55) | 8.8 ± 0.1a (+27.45) | 9.2 ± 0.1a (+33.09) | 8 ± 0.1b (+16.18) |
Values: mean ± SEM (n = 6).
Figures in parentheses indicate percent increase (+) or decrease (−).
Within a row those with different superscripts are significantly different (P < 0.002).
*HMG-CoA reductase activity is inversely proportional to the ratio of HMG-CoA/mevalonate (absorbance of HMG-CoA/absorbance of mevalonate), that is, the increase in ratio corresponds to a decrease in enzyme activity.
Comparisons for the percentage were made between groups NC and HC; HC and C-I; HC and C-II; HC and C-III.