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Wnt/β-catenin signaling pathway. A: In the absence of Wnt ligand, cytoplasmic b-catenin is targeted for destruction by the Axin–scaffolded protein complex containing Axin, APC, GSK3, and CKI. Association of DNA-bound Tcf with Gro and other transcriptional corepressors inhibits Wnt target genes. B: Upon ligand binding, the destruction complex is inhibited and cytoplasmic β-catenin accumulates and enters the nucleus where it can activate gene expression through Tcf and CBP binding.
