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Phosphorylation sites on Lef-1. Lef/Tcf family members can be phosphorylated by Nlk, CKI, and CK2. CK2 phosphorylates human Lef-1 at residues S42 and S61 within the β-catenin binding domain (β-cat BD). Nlk can phosphorylate Lef-1 at residues T155 and S166, as well as in the corresponding T178 and T189 in Tcf4. The HMG DNA-binding domain (DNAB) is at the C-terminus of the protein.
