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Time-kill curves of MIC of silibinin alone and its combination with MIC50 of ampicillin or gentamicin against S. mutans, S. sanguinis, S. sobrinus, S. anginosus, S. criceti, and S. ratti. Bacteria were incubated with silibinin (•), silibinin + ampicillin (∘), and silibinin + gentamicin (▾) over time. Data points are the mean values ± S.E.M. of six experiments. CFU: colony-forming units.
