Table 2.

Single marker associations for the four genes with subgroups of alcoholism

Gene	Control (n = 530)		EOA (n = 236)			LOA (n = 336)
	Marker	FControl	FCase	OR	pa	FCase	OR	pa
DRD2	rs2242592	0.258	0.288	1.17	.23	0.295	1.21	.10
	rs6279	0.267	0.290	1.12	.38	0.298	1.17	.16
	rs2587548	0.376	0.410	1.15	.23	0.398	1.10	.38
	rs1076563	0.380	0.410	1.13	.28	0.394	1.06	.61
	rs1079596	0.169	0.172	1.03	.88	0.855	1.19	.22
	rs1125394	0.165	0.178	1.10	.55	0.857	1.18	.24
	rs2471857	0.171	0.172	1.01	.94	0.857	1.23	.14
	rs4648318	0.226	0.249	1.14	.36	0.252	1.16	.22
	rs4274224	0.496	0.539	1.19	.13	0.541	1.20	.07
	rs4581480	0.877	0.901	1.28	.19	0.896	1.22	.24
	rs4648317	0.142	0.147	1.04	.81	0.164	1.19	.24
	rs4350392	0.831	0.850	1.15	.41	0.833	1.02	.95
	rs1799978	0.044	0.050	1.15	.59	0.046	1.05	.90
	rs12364283	0.075	0.082	1.10	.68	0.088	1.20	.31
HTR1B	rs2000292	0.735	0.741	1.03	.85	0.278	1.07	.57
	rs130060	0.951	0.980	2.44	.01	0.971	1.72	.05
	rs1213366	0.437	0.446	1.04	.78	.456	1.08	.45
OPRμ1	rs1799971	0.883	0.895	1.12	.54	0.898	1.16	.38
	rs510769	0.265	0.277	1.06	.66	0.758	1.14	.30
	rs3778151	0.164	0.176	1.09	.60	0.837	1.01	.95
	rs483021	0.947	0.948	1.02	1.00	0.961	1.35	.24
	rs660756	0.644	0.654	1.05	.73	0.680	1.18	.13
	rs1067684	0.095	0.107	1.15	.46	0.913	1.10	.61
	rs558025	0.731	0.767	1.22	.14	0.764	1.19	.14
	rs10485058	0.131	0.144	1.11	.51	0.171	1.36	.03
	rs548339	0.637	0.657	1.09	.49	0.679	1.20	.08
	rs569284	0.055	0.058	1.07	.81	0.962	1.45	.13
	rs2236256	0.531	0.541	1.04	.74	0.502	1.14	.21
	rs1918760	0.625	0.633	1.03	82	0.388	1.06	.61
	rs2281617	0.871	0.88	1.09	.67	0.150	1.19	.25
	rs6941251	0.572	0.608	1.16	.21	0.590	1.08	.48
	rs1998220	0.575	0.599	1.10	.40	0.587	1.05	.65
	rs9322451	0.82	0.837	1.12	.46	0.824	1.02	.90
	rs9479791	0.878	0.897	1.20	.34	0.889	1.11	.54
	rs790266	0.537	0.58	1.19	.13 0	.565	1.12	.27
	rs2272381	0.843	0.877	1.33	10 0	892	1.54	.005
	rs9371781	0.304	0.309	1.02	.86	0.339	1.18	.13
	rs6935927	0.573	0.594	1.09	.46	0.575	1.01	.96
	rs4314511	0.834	0.863	1.25	.17	0.847	1.10	.50
SLC6A4	rs3813034	0.602	0.621	1.08	.53	0.402	1.02	.88
	rs1042173	0.599	0.622	1.10	.42 0	.402	1.00	1.00
	rs3794808	0.612	0.626	1.06	.64	0.616	1.02	.92
	rs140701	0.62	0.623	1.01	.95	0.382	1.01	.96
	rs4583306	0.609	0.62	1.04	.73	0.615	1.02	.84
	rs2020942	0.399	0.407	1.03	.78 0	.402	1.01	.92
	rs6355	0.193	0.302	1.58	.19	0.988	1.61	.33
	rs2066713	0.393	0.399	1.03	.82	0.398	1.02	.84
	rs16965628	0.061	0.067	1.10	.73	0.944	1.10	.68
	rs2020933	0.049	0.054	1.11	.70	0.956	1.11	.72
	rs2020930	0.036	0.043	1.23	.47	0.973	1.32	.40

Notes: EOA = early-onset alcoholism (≤22 years); LOA = late-onset alcoholism (>22 years); OR = odds ratio; F_Case = risk allele frequency for cases; F_Control = risk allele frequency for controls.

^ap values adjusted for gender; p ≤ .01 indicated in bold.