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. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Annu Rev Neurosci. 2011;34:185–204. doi: 10.1146/annurev-neuro-061010-113613

Figure 3.

Figure 3

APP trafficking in neurons. Newly synthesized APP ( purple) is transported from the Golgi down the axon (1) or into a cell body endosomal compartment (2). After insertion into the cell surface, some APP is cleaved by α-secretase (6) generating the sAPPα fragment, which diffuses away ( green), and some is reinternalized into endosomes (3), where Aβ is generated (blue). Following proteolysis, the endosome recycles to the cell surface (4), releasing Aβ(blue) and sAPPβ. Transport from the endosomes to the Golgi prior to APP cleavage can also occur, mediated by retromers (5).