Table 3.
Antimicrobial treatment | Duration of hospitalization, median, days | CRP, mg/La | Deaths within 30 days | Deaths within 1 year |
1. Appropriate treatment (n = 50)b | 5 | |||
A. Empirical (n = 30) | 4 | 35 | 1 | 2 |
B. Delayed (n = 20) | 6 | 22 | 0 | 3 |
2. Inappropriate or no treatment (n = 26) | 3c | 26 | 1 | 1 |
3. Delayed, inappropriate, or no treatment (n = 46)d | 4c | 24 | 1 | 4 |
Pe | .008 (1 vs 2), .03 (1A vs 1B), NS (1A vs 3) | NS | NSf | NSf |
Median levels at hospital discharge, calculated for patients in whom this information was available 87%, 100%, and 77%, respectively, in groups 1A, 1B, and 2.
Appropriateness was defined according to antimicrobial susceptibility results (minimum inhibitory concentrations) of the bacterial isolates for gentamicin, meropenem, ciprofloxacin, erythromycin, and doxycycline.
The exact duration of hospitalization was not known for 1 patient in this group.
Group 3 = Groups 1B and 2 combined.
The Mann-Whitney test was used unless otherwise mentioned. Groups compared are indicated in parentheses; NS, not significant (P > .05).
Fisher’s exact test was used to compare mortality in groups 1 versus 2, 1A versus 1B, and 1A versus 3.