Table 2.

Questions That May Inform Dementia Screening in Aged Human Immunodeficiency Virus (HIV) Participants (Adapted From United States Preventative Service Task Force [USPSTF] Evidence Review for Dementia Screening in HIV-Negative Adults)

1) Does screening for cognitive impairment in primary care settings affect clinical outcomes?

2) What is the prevalence of undiagnosed cognitive impairment in primary care patients?

3) Does a reliable and valid screening test exist to detect cognitive impairment in older HIV patients?

4) Do pharmacological or non-pharmacological interventions, including care-giver interventions improve outcomes?

5) What are the adverse effects of screening for cognitive impairment?

6) What are the costs and cost-effectiveness of screening for cognitive impairment?

7) What are the side effects of treatment?

 Abbreviations: HAND, HIV-associated neurocognitive disorders; ANI, asymptomatic neurocognitive impairment.