Table 1.

Possible pharmacological actions of Radix Angelica Sinensis on cerebral infarction

Pharmacological actions	Related components	Possible mechanisms
Anti-arthrosclerosis effects	Danggui and sodium ferulate	reverse the reduction of TGB-β/reverse the increase of bFGF [24]
	Danggui	reduce the increase of serum malonyldialdehyde (MDA) levels [25]
	sodium ferulated	decrease the levels of triglyceride [11]
Vasodilatation and improving microcirculation effects	Danggui	increase the formation of NO and mediate the inhibition of calcium influx [10]
	sodium ferulate	increase the generation of NO [11]
	Ligustilide	inhibit prostaglandin F-2α, oxytocin, acetylcholine chloride, and potassium depolarization-induced muscle contraction [12]
	Ligustilide	increase the number of opened capillary and the speed of blood flow [13]
	Ferulic acid	enhance acetylcholine-induced vasodilatation and reduce the production of thromboxane B2 [14]
Anti-platelet aggregation effects	Danggui and sodium ferulate	inhibit ADP-induced and collagen-induced platelet aggregation [27]
	Z-Ligustilide	inhibit ADP-induced platelet aggregation [28]
Anti-inflammatory effects	Ferulic acid	inhibit ICAM-1 and NF-κB expression [33]
	Ferulic acid	enhance gamma-aminobutyric acid type B1 (GABAB1) receptor expression [34]
	Danggui	reduce TNF-α and TGF-ß1 mRNA expression [35]
	Danggui polysaccharides	reduce TNF-α levels [36]
Anti-oxidative effects	Ferulic acid	reduce the generation of NADPH-dependent production of superoxide anion [14]
	Ferulic acid	enhances the expression of GABAB1 receptor expression [34]
	Z-ligustilide	reduce MDA levels and increase GSH-PX and SOD activities [42]