. 2011 Sep 15;6(9):e23914. doi: 10.1371/journal.pone.0023914

Table 1. Respiratory parameters, oxygenation, histological injury scores and outcome after 4 hours of mechanical ventilation with low or high V_T.

Parameters	Spontaneous breathing	V_T 6 ml/kg	V_T 20 ml/kg	p-value
Peak airway pressure, cmH₂O	-	14±1	25±2	<0.0001
pH	-	7.39±0.03	7.42±0.02	0.076
PaCO₂, mmHg	-	41.3±2	38.7±2.2	0.060
PaO₂, mmHg	-	91±4	84±3	0.008
Histological lung injury score	0	2.1±0.3	7.8±1.1	<0.001
Lung fibrosis score	0	0.8±0.3	2.3±0.6	0.001
Mortality, %	0	0	0	-

Data are from 6 animals in each group. Numerical values are expressed as mean±SD. RR = respiratory rate; V_T = tidal volume.

Table 1. Respiratory parameters, oxygenation, histological injury scores and outcome after 4 hours of mechanical ventilation with low or high VT.