Table 1. Respiratory parameters, oxygenation, histological injury scores and outcome after 4 hours of mechanical ventilation with low or high VT.
Parameters | Spontaneous breathing | VT 6 ml/kg | VT 20 ml/kg | p-value |
Peak airway pressure, cmH2O | - | 14±1 | 25±2 | <0.0001 |
pH | - | 7.39±0.03 | 7.42±0.02 | 0.076 |
PaCO2, mmHg | - | 41.3±2 | 38.7±2.2 | 0.060 |
PaO2, mmHg | - | 91±4 | 84±3 | 0.008 |
Histological lung injury score | 0 | 2.1±0.3 | 7.8±1.1 | <0.001 |
Lung fibrosis score | 0 | 0.8±0.3 | 2.3±0.6 | 0.001 |
Mortality, % | 0 | 0 | 0 | - |
Data are from 6 animals in each group. Numerical values are expressed as mean±SD. RR = respiratory rate; VT = tidal volume.