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. 2011 Sep 15;6(9):e24263. doi: 10.1371/journal.pone.0024263

Figure 5. Dendritic remodeling of hippocampal CA3 pyramidal neurons.

Figure 5

(A) Left: A representative image of a selected neuron for analysis; Right: A neuronal morphology by using Neurolucida software (B) The soma size was not affacted by running and CORT treatment. (C) CORT treatment significantly decreased total dendritic length while running reversed the decrease. (D) The basal dendritic length was not affected by running and CORT treatmnet. The apical dendritic length was significantly increased by running in vehicle or CORT treated rats. (E) Running did not increase spine density in vehicle-treated rats, but restored the decrease in 40 mg/kg CORT-treated rats. (F) Treatment with 40 mg/kg CORT significantly decreased spine density in basal dendrites and apical dendrites. Running restored the decrease in spine density in 40 mg/kg CORT-treated rats. *P<0.05; **P<0.005. N = 3 for control non-runnes, N = 5-8 for the rest groups. Ctrl: control; 40 mg: 40 mg/kg CORT; N: non-runner; R:runner. Scale bar = 100 µm. FST: forced swim test.