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. 2011 Sep 15;6(9):e24537. doi: 10.1371/journal.pone.0024537

Figure 1. Cytotoxic effects of the acetonic extract of Buxus sempervirens L. towards breast cancer MCF7 and MCF10CA1a cells.

Figure 1

A. IC50 determined by the dose-response curves obtained by the MTT assay. B. C. D. and E. Different cell shapes exhibited by MCF7, MCF10CA1a, T47D, MDA-MB-435 and BT-20, respectively, treated with Buxus extract at their respective IC50 during 72 h. Left panel: phase contrast images; Right panel: anti-α-tubulin fluorescence staining. Control cells are treated with vehicle DMSO (magnification ×200). Ac Bux: acetonic Buxus extract.