Table 5. Canonical Pathways implicated in ASD when considering all genes versus highly expressed genes.
| Canonical Pathways Derived from All AutDB Genes | P-Value | Canonical Pathways Derived from 32 Highly Expressed ASD Genes | P-Value |
| Serotonin Receptor Signaling | 4.4E-08 | Corticotropin Releasing Hormone Signaling | 4.5E-05 |
| Reelin Signaling in Neurons** | 5.4E-06 | G-Protein Coupled Receptor Signaling** | 2.5E-04 |
| HER-2 Signaling in Breast Cancer | 5.0E-05 | Role of NFAT in Cardiac Hypertrophy | 3.1E-04 |
| cAMP-mediated Signaling** | 6.9E-05 | Reelin Signaling in Neurons**# | 3.7E-04 |
| G-Protein Coupled Receptor Signaling** | 7.6E-05 | Factors Promoting Cardiogenesis in Vertebrates | 5.0E-04 |
| Virus Entry via Endocytic Pathways** | 1.7E-04 | α-Adrenergic Signaling | 5.1E-04 |
| Macropinocytosis Signaling | 1.8E-04 | cAMP-mediated Signaling** | 5.1E-04 |
| Axonal Guidance Signaling | 2.2E-04 | Virus Entry via Endocytic Pathways** | 5.5E-04 |
| PTEN Signaling | 3.8E-04 | G Beta Gamma Signaling | 5.9E-04 |
| GABA Receptor Signaling | 4.3E-04 | Phospholipase C Signaling | 7.2E-04 |
| Glioblastoma Multiforme Signaling | 5.9E-04 | Cholecystokinin/Gastrin-mediated Signaling | 7.8E-04 |
| PI3K/AKT Signaling | 9.1E-04 | fMLP Signaling in Neutrophils | 9.5E-04 |
**indicates the pathway was implicated in both sets. #indicates the pathway was common to all three disorders.