Table 7. Canonical Pathways implicated in Epilepsy when considering all genes versus highly expressed genes.
| Canonical Pathways Derived from All Epilepsy Genes | P-Value | Canonical Pathways Derived from 42 Highly Expressed Epilepsy Genes | P-Value |
| GABA Receptor Signaling** | 4.7E-09 | Reelin Signaling in Neurons**# | 1.3E-06 |
| Neuropathic Pain Signaling In Dorsal Horn Neurons | 2.1E-06 | GABA Receptor Signaling** | 2.8E-04 |
| Reelin Signaling in Neurons** | 2.6E-05 | Semaphorin Signaling in Neurons | 7.1E-03 |
| β-alanine Metabolism | 2.2E-04 | Spliceosomal Cycle | 7.2E-03 |
| Glutamate Receptor Signaling** | 7.4E-04 | Glutamate Receptor Signaling** | 1.1E-02 |
| Calcium Signaling | 8.5E-04 | ||
| Cellular Effects of Sildenafil (Viagra) | 1.1E-03 | ||
| Butanoate Metabolism | 2.7E-03 | ||
| Hepatic Cholestasis | 5.5E-03 | ||
| Glutamate Metabolism | 6.0E-03 |
**indicates the pathway was implicated in both sets. #indicates the pathway was common to all three disorders.