Table 8. Cell-type specific protein expression of highly expressed ASD genes from the Human Protein Atlas database.
Neurons | Glia | Cerebellum | |||||||
Cortex | Hipp | Lat Vent | Cortex | Hipp | Lat Vent | Purkinje | Granular | Molecular | |
FABP7 | − | − | − | ++ | +++ | ++ | − | − | ++ |
GNAS | − | − | − | − | − | − | − | − | − |
GPX1 | + | + | − | ++ | ++ | ++ | ++ | − | − |
HNRNPH2 | +++ | +++ | +++ | +++ | ++ | ++ | ++ | +++ | +++ |
HRAS | +++ | +++ | +++ | +++ | +++ | +++ | − | +++ | +++ |
PDZD4 | ++ | + | ++ | + | + | +++ | ++ | − | ++ |
RPL10 | +++ | +++ | +++ | +++ | ++ | ++ | +++ | ++ | +++ |
TSPAN7 | +++ | ++ | ++ | − | − | − | − | − | − |
MAP2 | +++ | +++ | +++ | − | − | − | +++ | +++ | +++ |
PRKCB | ++ | ++ | ++ | − | − | + | ++ | +++ | ++ |
MEF2C | +++ | +++ | +++ | +++ | +++ | +++ | +++ | + | +++ |
RAPGEF4 | +++ | ++ | − | ++ | + | ++ | +++ | + | ++ |
APC | + | + | ++ | ++ | ++ | ++ | ++ | ++ | +++ |
DCX | +++ | + | + | ++ | ++ | ++ | ++ | ++ | +++ |
RIMS3 | + | + | + | − | − | − | + | ++ | − |
ROBO1 | ++ | ++ | ++ | +++ | ++ | ++ | ++ | ++ | ++ |
GLO1 | ++ | ++ | ++ | ++ | ++ | ++ | − | − | + |
DLX2 | +++ | ++ | ++ | + | + | + | ++ | + | − |
CNR1 | ++ | + | + | +++ | +++ | +++ | + | ++ | +++ |
PCDH10 | ++ | ++ | + | +++ | +++ | +++ | + | ++ | +++ |
NLGN3 | ++ | +++ | + | − | − | − | +++ | +++ | − |
RELN | + | + | + | − | − | − | + | − | − |
CADM1 | − | − | − | − | − | − | − | +++ | − |
CDH22 | + | − | − | + | + | + | − | ++ | − |
Data is reported as presented in the Atlas: +++ for “strong” expression, ++ for “moderate,” + for “weak,” and − for “negative.” These highly expressed ASD genes were not present in the database: Sez6l2, Gabrb3, Hsd11b1l, Hla-A, Dlx1, Adora2a, Cadps2, and DHCR7. Lat vent = Lateral Ventricle, Hipp = Hippocampus.