Table 9. Correlation of AutDB genes with published transcriptome studies in ASD brain.
| Garbet et al 2008 | Voineagu et al 2011 | Purcell et al 2001 | |
| Brain tissue studied | STC | STC, PFC, Cerebellum | Mainly Cerebellum |
| # of samples | 6 ASD, 6 Ctrls | 29 ASD, 29 Ctrls (cortex) 11ASD, 10 Ctrl (cerebellum) | 10 ASD, 23 Ctrls |
| Transcriptome Profiling Method | U133 Plus 2.0 GeneChip (Affymetrix) | Ref8 v3 Array (Illumina) | Clontech Array and UniGEM V2 Array |
| # of genes dysregulated in ASD | 130 | 444 | 30 |
| Main findings | ↑ Immune-related genes | Genes converge on immune and synapse modules | ↑ AMPA-type glutamate receptors |
| ↓ Genes involved in neuronal development | |||
| Dysregulated genes in AutDB | 4/130 (3%)1 | 21/444 (4.7%)2 | 1/31 (3.2%)3 |
1
SDC2, SLC9A9, DLX1, AHI1.
2
CD44, CDH10, DLX1, DPP6, GABRB3, HLA-A, KCNMA1, MET, NOS2A, PRKCB1, PTGS2, SCN1A, SLC25A12, NLGN4Y, CADM1, A2BP1, AHI1, PCDH10, PDZD4, CADPS2, SLC9A9.
3
CNR1.
STC = Superior temporal cortex, PFC = Pre-frontal cortex, cere = cerebellum.