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. 2011 Sep 15;6(9):e24840. doi: 10.1371/journal.pone.0024840

Figure 5. Deletion of the FKBP5 gene does not alter learning and memory despite robust expression of FKBP5 in the hippocampus.

Figure 5

(A) Discrimination index between familiar and novel object in the novel object recognition test. (B) Percent of spontaneous alternation shows no difference between the groups. (C) Learning of the location of the hidden platform in the MWM (interaction F(5,80) = 0.14, p = 0.98; genotype F(1,16) = 0.0, p = 0.98; time F(5,80) = 12.71, p<0.0001). (D) Percent time spent in quadrant during the probe trial of MWM. (E) Software generated heat plot representing amount of time spent in an area. (F) Percent freezing during training portion of fear conditioning; interaction F(6,90) = 4.1, **p = 0.001; genotype F(1,15) = 5.66, *p = 0.031; time F(6,90) = 79.89, ***p<0.0001; Bonferroni multiple comparisons wt vs FKBP5−/− at 240 s, t = 2.42, ***p<0.001. (G) Percent freezing during contextual exposure to fear-conditioning chamber. (H) Percent freezing during the cued fear-conditioning test; interaction F(1,30) = 0.05, p = 0.828; genotype F(1,30) = 0.25, p = 0.624; tone F(1,30) = 55.75, ***p<0.0001.