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. 2011 Sep 15;7(9):e1002283. doi: 10.1371/journal.pgen.1002283

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Charneski et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Skew calculated in 40 kb non-overlapping windows is shown with respect to the published strand. The origin of replication is near 0 kb and the terminus of replication is expected to coincide at the midpoint where the skew changes direction. Excluding non-core (denoted by blue regions) eliminates an A-rich peak at approximately 2,300 kb into the genome.