Table 3. Haplotype Frequencies Distributions of Significant Haplotype Blocks among Cases and Controls.

Haplotype	Candidate Gene Study							Replication Study
	SNPs	Alleleg	Freq		Chi Sq	P	P h	SNPs	Alleleg	Freq		Chi Sq	P	P h
			Case	Control						Case	Control
SHMT1-CCG	rs2273028	C/T	0.364	0.299	6.69	9.71x10-3	0.78	rs2273028	C/T	0.339	0.312	1.434	0.23	0.96
	rs11868708	T/C						rs9909104i	T/C
	rs2273026	G/A						rs2273026	G/A
TCN2-GA	rs5749131	A/G	0.042	0.085	11.12	8.54x10-4	0.13	rs5749131	A/G	0.063	0.06	0.094	0.76	1
	rs11703570	A/T						rs2301955j	C/T

^gMajor alleles given first, minor alleles second.

^h1000 permutations performed.

ⁱr² = 1 with rs11868708.

^jr² = 1 with rs11703570.