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. 2011 Sep 16;6(9):e24852. doi: 10.1371/journal.pone.0024852

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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The frequency of each T cell subset was compared between adults (≥18 years old) and children (≤5 years old) for (A) Central memory, T_CM: CD4⁺ CD45RA⁻ CD62L⁺; (B) naïve T cells, T_N: CD4⁺ CD45RA⁺ CD62L⁺; (C) effector memory, T_EM: CD4⁺ CD45RA⁻ CD62L⁻; and (D) RA-expressing effector memory, T_EMRA: CD4⁺ CD45RA⁺ CD62L⁻. The median frequency of CD4⁺ T_CM and T_EM was significantly lower for children compared to adults (P<0.001, Mann Whitney test). Whereas the median frequency of CD4⁺ T_N was significantly higher for children compared with adults (P<0.001). The median frequency of CD4⁺ T_EMRA was similar for the two age groups (P = 0.719).