Table 1. Risk estimates for male breast cancer conferred by 12 loci identified through GWAS of female breast cancer.

SNP	Chromosome	Gene	Risk Allelea	Risk Allele Freq	Male breast cancer				Female breast cancerb
					OR(het)	OR(hom)	OR(trend)	P(trend)	OR(trend)	P(trend)
rs11249433	1p11.2	NOTCH2	C	0.42	1.07	1.28	1.12	0.13	1.20 [13]	4.48−10−13
					(0.84–1.36)	(0.94–1.73)	(0.97–1.31)		(1.14–1.25)
rs13387042	2q35		A	0.50	1.31	1.69	1.30	7.98−10−04	1.12 [11]	1.00−10−19
					(1.00–1.73)	(1.24–2.29)	(1.11–1.51)		(1.09–1.15)
rs4973768	3p24.1	SLC4A7	T	0.47	1.05	1.28	1.13	0.11	1.11 [8]	1.40−10−18
					(0.81–1.36)	(0.95–1.74)	(0.97–1.32)		(1.08–1.13)
rs10941679	5p12		G	0.27	1.28	1.54	1.26	0.007	1.19 [12]	2.90−10−11
					(1.02–1.60)	(1.04–2.29)	(1.07–1.48)		(1.13–1.26)
rs16886165	5q11.2	MAP3K1	G	0.16	0.99	0.85	0.97	0.77	1.23 [13]	5.00−10−07
					(0.78–1.26)	(0.41–1.78)	(0.79–1.19)		(1.12–1.35)
rs9383938	6q25.1	ESR1	T	0.09	1.31	2.79	1.39	0.01	1.18 [10]	1.41−10−07
					(0.99–1.73)	(1.11–7.00)	(1.09–1.78)		(1.11–1.26)
rs13281615	8q24.21		G	0.41	0.97	1.20	1.07	0.37	1.08 [9]	5.00−10−12
					(0.76–1.23)	(0.88–1.64)	(0.92–1.25)		(1.05–1.11)
rs865686	9q31.2		T	0.62	1.07	1.10	1.04	0.62	1.11[10]	1.75−10−10
					(0.77–1.49)	(0.78–1.53)	(0.89–1.22)		(1.04 -1.19)
rs2981579	10q26.13	FGFR2	T	0.42	1.06	1.43	1.18	0.03	1.26 [9] , [14]	2.00−10−76
					(0.83–1.36)	(1.06–1.94)	(1.02–1.38)		(1.23–1.30)
rs3817198	11p15.5	LSP1	C	0.32	0.94	0.87	0.93	0.39	1.07 [9]	3.00−10−09
					(0.75–1.89)	(0.60–1.25)	(0.79–1.09)		(1.04 -1.11)
rs3803662	16q12.1	TOX3	T	0.27	1.48	2.21	1.48	4.04−10−06	1.20 [9]	1.00−10−36
					(1.18–1.85)	(1.50–3.25)	(1.26–1.75)		(1.16–1.24)
rs6504950	17q22	COX11	G	0.72	0.86	0.79	0.90	0.22	1.05 [8]	1.40×10−08
					(0.58–1.28)	(0.53–1.17)	(0.76–1.06)		(1.03–1.07)

^aRisk allele for female breast cancer.

^bFemale association statistics and effect estimates from previously published data.