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. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Nat Neurosci. 2010 Oct 31;13(12):1526–1533. doi: 10.1038/nn.2682

Figure 2.

Figure 2

Photoinhibition of locus coeruleus neurons causes a reduction in the duration of wakefulness. (a) The percentage of time spent in wake, NREM, and REM sleep during 1 h photoinhibition in the active (dark) period. Data represent the mean +/– s.e.m. of 6 separate 1 h sessions, n=6 animals throughout. *P<0.05, two-tailed Student's t-test between transduced animals. (b) The duration of individual wake, NREM, and REM episodes during 1 h photoinhibition during the active period. *P<0.05, two-tailed Student's t-test between transduced animals. (c) The percentage of sleep state transitions relative to baseline levels during 1 h photoinhibition during the active period. **P<0.001, two-tailed Student's t-test between transduced animals. (d) The duration of individual wake episodes in baseline versus photoinhibition conditions (20 episodes per mouse, n=6 mice). *P<0.05, two-way ANOVA between stimulation condition and viral transduction followed by Tukey posthoc test. (e) Relative EEG power of wakefulness between 80-120 s after wake-onset in baseline (top) and photoinhibition (bottom) conditions. Data represent the mean +/– s.e.m. relative power of 0.5 Hz binned frequencies (20 episodes per mouse, n=6 mice).