Figure 1.

Effect of ranolazine on late sodium currents (I_Na,L) in rabbit myocytes. A. The superimposed currents show responses to step depolarizations ranging from −140 to −20 mV from a holding potential of −140 mV, obtained under control conditions and after 3 min of superfusion with various concentrations of ranolazine. B. Concentration–response relationship of ranolazine on I_Na,L. The amplitude of I_Na,L was measured at 200 ms after membrane depolarization. Data were fitted with an equation I/I_o = 1/(1 +[C]/[IC₅₀]). Data were expressed as Mean ± SEM, n = 8, two cells per rabbit.