Figure 3.

Effects of pretreatment of mesenteric arteries with an inhibitor of NOS on 2-furoyl-LIGRLO-amide (2fly)-, ACh- and nitroprusside-induced relaxations in db/db and C57BL/6J (C57) mice. Values are the mean ± SE (n = number of mice) for (A, B) 2fly- (C, D) ACh-, and nitroprusside (E, F) induced relaxations of C57 and db/db second order mesenteric arteries contracted submaximally by U46619 in the absence or presence of pretreatment with l-NAME (100 µM, 20 min). *P < 0.05, C57 untreated (control) compared with l-NAME in (A) –logEC₅₀ and hill slope (C) E_max, 2-way anova and Bonferroni post hoc test.