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Concentrations of EGIS-8332 in the plasma and brain of 7-month-old Cln3Δex1-6 mice at different time points after a single i.p. administration (1 mg/kg); n=4 mice at each time point. EGIS-8332 levels were measured by HPLC-MS/MS.
| Time after administration | Plasma, ng/ml | Brain, ng/g |
|---|---|---|
| 15 min | 837.0±116.0 | 81.1±12.6 |
| 1 h | 233.7±18.1 | 41.5±9.6 |
| 3 h | 21.7±5.6 | 3.0±1.0 |
| 8 h | 1.3±0.1 | ND |
| 24 h | ND | ND |
| 48 h | ND | ND |
ND: non-detectable
